I am very impressed with the study design and the results of the work of Dr. C. David Rollo of McMaster University in Canada featured in the May 2012 issue of Life Extension Magazine.
You can access the article here. He and other researchers developed a “cocktail” of nutritional supplements showing a significantly increased life span in laboratory animals. The reason I was so thrilled by this study is that of the 30 nutrients that were put into the cocktail, based on past research that they all affect positively the five fundamental causes of aging, 26 of them are included in various components of my priority recommendations to my patients seeking optimal health through the Synergistic Health approach.
The first tenant of Synergistic Health is that there is a certain critical number of proven, well-researched, and proven beneficial health steps such as vitamin and nutritional supplementation, hormone balancing, improvement in diet will move a patient in to a most sure trajectory towards attainment of their health goal or prevention of their disease process. Instead of just getting additive benefit, at some critical mass or some certain combination one moves into a synergistic effect-where the sum of the expected benefits is many times greater than the predicted benefit of any one supplement or health step. It appears Dr. Rollo and associated researches proved this primary Synergistic Health tenant.
If the mixture of nutrients, or one like it, has similar effectiveness in humans, one could expect an 80-year-old to add nearly 9 years of life, with youthful levels of activity and cognition.
The 30 nutrients listed are: Vitamin B1,Vitamin B3, Vitamin B6, Vitamin B 12, Folate, Vitamin C, Vitamin D, Acetyl–L-Carnitine, Alpha-Lipoic acid, Acetylsalicyclic acid(aspirin), Beta-Carotene, Bioflavenoids, Chromium picolinate, Garlic, Ginger root extract, Ginkgo biloba, Ginseng, Green tea extract, L-Glutathione, Magnesium, Manganese, Melatonin, N-Acetyl cysteine, Potassium, Rutin, Selenium, Vitamin E, Cod Liver Oil (omega-3 oil), Coenzyme Q 10, Flax Seed Oil.
The five fundamental causes of aging are: oxidative stress, inflammation, mitochondrial dysfunction, insulin resistance, and integrity of membranes.